Description

3-(3-Chloro-4-Fluorophenyl)-2-(4-Ethoxyphenyl)-2,3-Dihydro-4(1H)-Quinazolinone is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop next-generation drug candidates with potential applications in oncology and central nervous system disorders.

Application

• Primary building block for the synthesis of novel quinazolinone-based pharmaceutical compounds.
• Key intermediate in research and development of potential kinase inhibitors for oncology applications.
• Precursor in the development of advanced chemical entities for central nervous system (CNS) drug discovery programs.
• Used in process chemistry and scale-up studies for new Active Pharmaceutical Ingredients (APIs).
• Valuable reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Starting material for academic and industrial research into heterocyclic chemistry and medicinal chemistry.

Basic Information

Product Name	3-(3-Chloro-4-Fluorophenyl)-2-(4-Ethoxyphenyl)-2,3-Dihydro-4(1H)-Quinazolinone
CAS No.	312536-10-0
Molecular Formula	C22H18ClFN2O2
Molecular Weight	396.84 g/mol
Synonyms	3-(3-Chloro-4-fluorophenyl)-2-(4-ethoxyphenyl)-3,4-dihydro-2H-quinazolin-4-one; 2-(4-Ethoxyphenyl)-3-(3-chloro-4-fluorophenyl)-2,3-dihydroquinazolin-4(1H)-one; 312536-10-0; Quinazolinone derivative, 3-(3-chloro-4-fluorophenyl)-2-(4-ethoxyphenyl)-2,3-dihydro-4(1H)-one; 2,3-Dihydro-4(1H)-quinazolinone, 3-(3-chloro-4-fluorophenyl)-2-(4-ethoxyphenyl)-; 3-(3-Chloro-4-fluorophenyl)-2-(4-ethoxyphenyl)-1,2,3,4-tetrahydroquinazolin-4-one
EINECS	Contact for details

Quality Control

Our 3-(3-Chloro-4-Fluorophenyl)-2-(4-Ethoxyphenyl)-2,3-Dihydro-4(1H)-Quinazolinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with full traceability are provided and specifications can be aligned with cGMP and ICH Q7 guidelines for pharmaceutical intermediates upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive and should be stored away from light. Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.