Description

2-(Chloromethyl)-3-[3-(Trifluoromethyl)Phenyl]-4(3H)-Quinazolinone is a high-value, synthetically versatile heterocyclic compound that serves as a critical building block in advanced organic synthesis. Its molecular architecture, featuring a reactive chloromethyl group and a trifluoromethylphenyl moiety, makes it an essential intermediate for developing novel active pharmaceutical ingredients (APIs) and functional materials. This compound is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating compounds with enhanced biological activity and specific physicochemical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinazolinone-based drug candidates, particularly for oncology and central nervous system (CNS) targets.
• Agrochemical Research: Used in developing next-generation herbicides and fungicides, where the trifluoromethyl group can improve metabolic stability and bioavailability.
• Material Science: Serves as a monomer or functional additive in the creation of advanced polymers and liquid crystals with specific optical or electronic properties.
• Chemical Biology Probe Development: Employed in medicinal chemistry to build tool compounds for studying enzyme inhibition and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring complex, fluorinated heterocyclic structures.

Basic Information

Product Name	2-(Chloromethyl)-3-[3-(Trifluoromethyl)Phenyl]-4(3H)-Quinazolinone
CAS No.	312510-67-1
Molecular Formula	C₁₆H₁₀ClF₃N₂O
Molecular Weight	338.71 g/mol
Synonyms	2-(Chloromethyl)-3-[3-(trifluoromethyl)phenyl]-4(3H)-quinazolinone; 3-[3-(Trifluoromethyl)phenyl]-2-(chloromethyl)-4(3H)-quinazolinone; 2-Chloromethyl-3-(3-trifluoromethylphenyl)-4(3H)-quinazolinone; 4(3H)-Quinazolinone, 2-(chloromethyl)-3-[3-(trifluoromethyl)phenyl]-; CAS 312510-67-1
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for this advanced intermediate. Production follows current Good Manufacturing Practices (cGMP) where applicable, and every batch is analyzed using validated methods including HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.