Description

Neuromedin U-25 (Human) is a bioactive neuropeptide fragment consisting of 25 amino acid residues. This compound is a specific agonist for the neuromedin U receptors (NMUR1 and NMUR2), playing a significant role in regulating energy homeostasis, appetite, and gastrointestinal motility. It is an essential research-grade biochemical for neuroscientists, pharmacologists, and drug discovery teams. The product is supplied as a high-purity lyophilized powder, suitable for in vitro and in vivo research applications.

Application

• Neuroscience Research: Investigating the role of neuromedin U in central nervous system functions, including stress response, feeding behavior, and circadian rhythms.
• Pharmacology Studies: Used as a reference standard and tool compound for characterizing NMU receptor signaling pathways and validating receptor binding assays.
• Drug Discovery & Development: Screening for novel therapeutics targeting metabolic disorders, obesity, and gastrointestinal diseases.
• Biochemical Assays: Serving as a critical reagent in cell-based functional assays (e.g., calcium flux, cAMP measurement) to study receptor activation and downstream effects.
• Academic & Institutional Research: Fundamental research into peptide hormone biology and neuroendocrine regulation.

Basic Information

Product Name	Neuromedin U-25 (Human)
CAS No.	312306-89-1
Molecular Formula	C₁₂₇H₂₁₀N₄₂O₃₈S₂
Molecular Weight	2951.4 g/mol
Synonyms	Neuromedin U-25, NMU-25, hNMU-25; Neuromedin U (Human); NMU (25-53) (Human); Tyr-Lys-Val-Asn-Glu-Tyr-Glu-Leu-Arg-Arg-Tyr-Gln-Arg-Phe-Asn-Ser-Phe-Arg-Pro-Arg-Asn-NH2 (Disulfide bridge: Cys8-Cys16); TKYNEYELRRYQRFNSFPRN-NH2 (Disulfide bridge); CAS 312306-89-1
EINECS	Contact for details

Quality Control

Our Neuromedin U-25 (Human) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing purity, peptide content, and endotoxin levels are provided to ensure the material meets the stringent requirements for biomedical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Amino Acid Composition	Within ±10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.