Description

Tyr-Leptin (26-39) (Human) is a synthetic peptide fragment corresponding to the 26-39 sequence of human leptin, modified with a tyrosine residue. This compound is a critical research-grade biochemical tool for studying leptin signaling pathways, receptor interactions, and metabolic regulation. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on endocrinology, obesity research, and metabolic disorder therapeutics.

Application

• Biochemical Research: Used as a reference standard and active agent in studies investigating the structure-activity relationship (SAR) of leptin.
• Receptor Binding Assays: Essential for in vitro competitive binding studies to characterize leptin receptor (LEPR) affinity and specificity.
• Metabolic Pathway Analysis: A key tool for probing the role of specific leptin domains in signaling cascades related to appetite, energy expenditure, and glucose homeostasis.
• Antibody Production & Immunoassays: Serves as an immunogen for generating specific antibodies or as a calibrator in ELISA and other immunoassay development for leptin detection.
• Pharmaceutical Development: Supports early-stage drug discovery programs aimed at developing leptin analogs or modulators for treating metabolic diseases.

Basic Information

Product Name	Tyr-Leptin (26-39) (Human)
CAS No.	309247-25-4
Molecular Formula	C79H124N22O23S
Molecular Weight	1742.0 g/mol
Synonyms	Leptin (26-39) (human) tyrosine derivative; Tyr-hLeptin(26-39); Human Leptin Fragment 26-39 (Tyr); LEP (26-39), Human (Tyr); [Tyr26]Leptin(26-39); Obese protein (26-39) fragment (human) with N-terminal Tyr; Tyr-Leptin 26-39; Peptide LEP 26-39 (Tyr)
EINECS	Contact for details

Quality Control

Our Tyr-Leptin (26-39) (Human) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and content. We adhere to relevant guidelines for research chemicals, ensuring reliable performance in sensitive biological assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.