Description

L-Norleucine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-4,4-Dimethyl- is a protected amino acid derivative, specifically an Fmoc-protected norleucine analog with a dimethyl substitution. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of a non-natural, hydrophobic amino acid residue into peptide chains. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and the production of custom peptides for therapeutic and diagnostic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected derivative, it is a fundamental reagent for the automated synthesis of custom peptides.
• Pharmaceutical Research & Development: Used to create peptide-based drug candidates, particularly those requiring enhanced metabolic stability or altered hydrophobicity.
• Bioconjugation and Probe Development: Serves as a modified amino acid for introducing specific functional groups or labels into peptides and proteins.
• Structure-Activity Relationship (SAR) Studies: The 4,4-dimethyl norleucine side chain is used to investigate the role of steric bulk and hydrophobicity in peptide-receptor interactions.
• Production of Non-Natural Peptide Libraries: Key for generating diverse peptide libraries for high-throughput screening in drug discovery.
• Academic and Industrial Biochemistry: Employed in studies of protein folding, enzyme specificity, and as a tool in chemical biology.

Basic Information

Product Name	L-Norleucine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-4,4-Dimethyl-
CAS No.	308807-06-9
Molecular Formula	C23H27NO4
Molecular Weight	381.47 g/mol
Synonyms	Fmoc-4,4-dimethyl-L-norleucine; Fmoc-Dml-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4,4-dimethyl-L-norleucine; Fmoc-4-Me2-Nle-OH; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4,4-dimethylpentanoic acid; Fmoc-4,4-diMeLeu-OH; Fmoc-dimethylnorleucine; N-α-Fmoc-4,4-dimethyl-L-norleucine
EINECS	Contact for details

Quality Control

Our Fmoc-protected amino acids are manufactured under strict quality systems to ensure the high purity and consistency required for sensitive synthetic applications. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and optical rotation analysis, to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and cGMP documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain quality. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.