Description

(Glu24)-Glucagon (1-29) (Human, Rat, Porcine) CAS NO 308356-99-2 is a synthetic peptide analog of glucagon, a key hormone involved in glucose metabolism. This high-purity compound is critical for advanced pharmaceutical research and development, particularly in metabolic studies and therapeutic applications. It is primarily utilized by biopharmaceutical companies, academic research institutions, and contract research organizations (CROs) focused on endocrinology, diabetes research, and peptide-based drug discovery.

Application

• Pharmaceutical Reference Standard: Serves as a critical benchmark for quality control and analytical method development in the production of glucagon and related peptide therapeutics.
• Metabolic Disease Research: Used in in vitro and in vivo studies to investigate hepatic glucose production, insulin secretion counter-regulation, and pathways relevant to diabetes and hypoglycemia.
• Receptor Binding & Signal Transduction Studies: Essential for characterizing the binding affinity and functional activity at the glucagon receptor (GCGR) in cell-based assays.
• Peptide Chemistry & Formulation Development: Acts as a model compound for studying peptide stability, solubility, and the development of novel delivery systems for peptide hormones.
• Biochemical Tool Compound: Employed in enzymatic assays, antibody development, and as a calibrant in mass spectrometry and HPLC analysis within diagnostic and research settings.

Basic Information

Product Name	(Glu24)-Glucagon (1-29) (Human, Rat, Porcine)
CAS No.	308356-99-2
Molecular Formula	C153H225N43O49S
Molecular Weight	3483.8 g/mol
Synonyms	Glucagon (1-29), human; Glucagon, human; H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH; [Glu24]Glucagon; Glucagon, porcine; Glucagon, rat; Glucagon fragment 1-29; GCGR agonist peptide
EINECS	Contact for details

Quality Control

Our (Glu24)-Glucagon (1-29) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for peptide synthesis, and material can be supplied to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate. Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 15.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.