Description

6-Bromo-4-(Pyrrolidin-1-Yl)Quinazoline is a high-purity, advanced pharmaceutical intermediate characterized by its distinct quinazoline core functionalized with a bromo substituent and a pyrrolidine moiety. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of targeted kinase inhibitors and other bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutics for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of small-molecule drug candidates, particularly protein kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new therapeutic agents.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds to study specific biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical trial materials.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	6-Bromo-4-(Pyrrolidin-1-Yl)Quinazoline
CAS No.	307538-51-8
Molecular Formula	C₁₂H₁₂BrN₃
Molecular Weight	278.15 g/mol
Synonyms	4-(1-Pyrrolidinyl)-6-bromoquinazoline; 6-Bromo-4-pyrrolidin-1-ylquinazoline; Quinazoline, 6-bromo-4-(1-pyrrolidinyl)-; 307538-51-8; 6-Bromo-4-pyrrolidinoquinazoline; 4-(Pyrrolidin-1-yl)-6-bromoquinazoline
EINECS	Contact for details

Quality Control

Our 6-Bromo-4-(Pyrrolidin-1-Yl)Quinazoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.