Description

4-(3,5-Difluorophenoxy)Aniline is a high-purity fluorinated aniline derivative, serving as a critical advanced pharmaceutical intermediate (API) and fine chemical building block. Its value lies in its unique molecular structure, which incorporates both an aniline moiety and a difluorophenoxy group, enabling precise modifications in complex organic syntheses. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and specialty polymers.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for the synthesis of fluorinated aromatic diamines and other monomers used in high-performance liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Acts as a monomer or chain modifier in the production of specialty polyimides, polyamides, and epoxy resins, imparting improved thermal stability and chemical resistance.
• Dye & Pigment Industry: Intermediate for creating novel fluorinated azo dyes and pigments with enhanced color fastness and solubility properties.
• Cross-Coupling Reactions: Valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) for constructing complex biaryl amine structures in medicinal chemistry.

Basic Information

Product Name	4-(3,5-Difluorophenoxy)Aniline
CAS No.	307308-83-4
Molecular Formula	C12H9F2NO
Molecular Weight	221.20 g/mol
Synonyms	4-(3,5-Difluorophenoxy)benzenamine; 4-Amino(3,5-difluorophenoxy)benzene; Benzenamine, 4-(3,5-difluorophenoxy)-; 3,5-Difluorophenyl 4-aminophenyl ether; 4-(3,5-Difluorophenoxy)phenylamine; AN-698/30730883; 1-Amino-4-(3,5-difluorophenoxy)benzene
EINECS	Contact for details

Quality Control

Our 4-(3,5-Difluorophenoxy)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	85 - 89 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.