Description

2-Trifluoromethyl-Pyrimidine-5-Carbaldehyde is a high-value fluorinated pyrimidine building block essential for advanced organic synthesis. This compound matters as a versatile aldehyde intermediate, enabling the introduction of the trifluoromethyl-pyrimidine pharmacophore into target molecules, which is critical for modulating biological activity and physicochemical properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, leveraging the biological activity of the trifluoromethylpyrimidine moiety.
• Material Science Research: Serves as a precursor for functionalized ligands and organic electronic materials.
• Cross-Coupling Reactions: The aldehyde group facilitates further derivatization via condensation, reductive amination, or nucleophilic addition reactions.
• Library Synthesis: Employed in combinatorial and medicinal chemistry for the rapid generation of diverse compound libraries for screening.

Basic Information

Product Name	2-Trifluoromethyl-Pyrimidine-5-Carbaldehyde
CAS No.	304693-66-1
Molecular Formula	C6H3F3N2O
Molecular Weight	176.10 g/mol
Synonyms	5-Formyl-2-(trifluoromethyl)pyrimidine; Pyrimidine-5-carboxaldehyde, 2-(trifluoromethyl)-; 2-(Trifluoromethyl)pyrimidine-5-carbaldehyde; 2-Trifluoromethyl-5-pyrimidinecarboxaldehyde; 304693-66-1; 2-Trifluoromethylpyrimidine-5-carboxaldehyde
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethyl-Pyrimidine-5-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.