Description

1,1,1-Trifluoro-4-(2-Hydroxy-Phenylamino)-Pent-3-En-2-One is a specialized fluorinated organic compound featuring a β-enaminone scaffold, making it a valuable intermediate for advanced chemical synthesis. Its structure is engineered to serve as a key building block in the development of complex molecules, particularly in high-value research and manufacturing sectors. This product is essential for pharmaceutical R&D, agrochemical innovation, and the synthesis of functional materials where precise fluorination and specific molecular architecture are required.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a versatile ligand or precursor for metal-organic complexes used in asymmetric catalysis and material science.
• Fluorinated Fine Chemical Synthesis: Employed in organic synthesis to introduce the β-enaminone motif into more complex fluorinated structures for electronic and optical materials.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, particularly in reactions involving C–F bond formation and enamine chemistry.

Basic Information

Product Name	1,1,1-Trifluoro-4-(2-Hydroxy-Phenylamino)-Pent-3-En-2-One
CAS No.	303986-90-5
Molecular Formula	C11H10F3NO2
Molecular Weight	245.20 g/mol
Synonyms	4-(2-Hydroxyanilino)-1,1,1-trifluoropent-3-en-2-one; 1,1,1-Trifluoro-4-[(2-hydroxyphenyl)amino]pent-3-en-2-one; 4-(2-Hydroxyphenylamino)-1,1,1-trifluoropent-3-en-2-one; β-Enaminone Trifluoromethyl Derivative; TFHPO; (Z)-4-((2-Hydroxyphenyl)amino)-1,1,1-trifluoropent-3-en-2-one; Trifluoromethyl β-Enaminone Intermediate
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoro-4-(2-Hydroxy-Phenylamino)-Pent-3-En-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and industrial use. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.