Description

8-((2-Hydroxypropyl)Thio)-3-Methyl-7-(4-Methylbenzyl)-3,7-Dihydro-1H-Purine-2,6-Dione is a high-purity, synthetically derived xanthine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or active pharmaceutical ingredient (API) building block for the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical companies, biotechnology firms, and contract research organizations (CROs) engaged in drug discovery programs targeting neurological, cardiovascular, or inflammatory pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel adenosine receptor antagonists or phosphodiesterase (PDE) inhibitors.
• Drug Discovery Research: Used as a reference standard or lead compound in high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Neurological Agent Development: Potential precursor for compounds targeting neurodegenerative diseases like Parkinson's or Alzheimer's.
• Cardiovascular Drug Synthesis: Intermediate in the development of agents for treating heart failure, hypertension, or ischemia.
• Anti-inflammatory Agent Research: Utilized in the research of new non-steroidal anti-inflammatory drugs (NSAIDs) with modified purine backbones.
• Biochemical Tool Compound: Serves as a selective ligand or inhibitor in enzymatic and receptor binding assays to study purinergic signaling.
• Academic & Institutional Research: Used in university and government labs for fundamental pharmacological and medicinal chemistry studies.

Basic Information

Product Name	8-((2-Hydroxypropyl)Thio)-3-Methyl-7-(4-Methylbenzyl)-3,7-Dihydro-1H-Purine-2,6-Dione
CAS No.	303970-23-2
Molecular Formula	C₁₇H₂₀N₄O₃S
Molecular Weight	360.43 g/mol
Synonyms	8-[(2-Hydroxypropyl)sulfanyl]-3-methyl-7-[(4-methylphenyl)methyl]-1H-purine-2,6-dione; 3-Methyl-7-(4-methylbenzyl)-8-((2-hydroxypropyl)thio)-3,7-dihydro-1H-purine-2,6-dione; 8-(2-Hydroxypropylthio)-3-methyl-7-(4-methylbenzyl)xanthine; 7-(4-Methylbenzyl)-8-((2-hydroxypropyl)thio)-3-methylxanthine; Xanthine derivative, 8-(2-hydroxypropylthio)-3-methyl-7-(4-methylbenzyl)-; Purine-2,6-dione, 8-((2-hydroxypropyl)thio)-3-methyl-7-(4-methylbenzyl)-3,7-dihydro-1H-
EINECS	Contact for details

Quality Control

Our production of this high-value pharmaceutical intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and traceability. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profile. We support development and commercial projects with material produced under GMP-like conditions where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, the container should be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.