Description

(Leu31,Pro34)-Neuropeptide Y (13-36) (Human, Rat) is a synthetic peptide fragment derived from the neuropeptide Y (NPY) sequence, specifically designed as a potent and selective antagonist for the Y1 receptor subtype. This compound is a critical research tool for elucidating the complex roles of NPY in physiological and pathological processes, including appetite regulation, anxiety, and cardiovascular function. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, metabolic disorder, and cardiovascular disease research.

Application

• Neuroscience Research: Used as a selective Y1 receptor antagonist to study NPY's role in anxiety, stress response, depression, and seizure activity.
• Metabolic Disorder Studies: Investigates the mechanisms of NPY in appetite stimulation, energy homeostasis, and obesity, providing insights for potential therapeutic targets.
• Cardiovascular Research: Applied in studies exploring NPY's effects on blood pressure regulation, vascular tone, and heart function.
• Receptor Binding Assays: Serves as a high-affinity ligand in competitive binding experiments to characterize Y1 receptor pharmacology and screen for novel modulators.
• Signal Transduction Studies: Helps delineate intracellular signaling pathways (e.g., inhibition of cAMP accumulation) activated upon Y1 receptor binding.
• In Vivo Pharmacological Models: Administered in animal models to assess the physiological consequences of selective Y1 receptor blockade.

Basic Information

Item	Details
Product Name	(Leu31,Pro34)-Neuropeptide Y (13-36) (Human, Rat)
CAS No.	302798-54-5
Molecular Formula	C117H184N34O33
Molecular Weight	Contact for details
Synonyms	(Leu31,Pro34)-NPY (13-36); NPY (13-36), (Leu31,Pro34)-; [Leu31,Pro34]NPY(13-36); Neuropeptide Y (13-36) fragment, (Leu31,Pro34)-substituted; NPY Y1 receptor antagonist (13-36); Human, Rat (Leu31,Pro34)-NPY (13-36); [Leu31, Pro34] Neuropeptide Y (13-36)
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality management systems. Each batch of (Leu31,Pro34)-Neuropeptide Y (13-36) (Human, Rat) undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, content, and analytical results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider keeping the lyophilized powder under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Amino Acid Analysis	Within ± 10% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.