Description

2,5-Anhydro-3-Deoxy-3-(5-Fluoro-3,4-Dihydro-2,4-Dioxo-1(2H)-Pyrimidinyl)-D-Mannitol is a high-value fluorinated nucleoside derivative, a key intermediate in the synthesis of novel antiviral and anticancer therapeutics. Its precise chemical structure, incorporating a modified sugar moiety linked to a fluorinated pyrimidine base, is critical for imparting enhanced metabolic stability and target specificity to the final active pharmaceutical ingredient (API). This compound is essential for research and development laboratories, as well as production facilities, in the pharmaceutical and biotechnology sectors focused on nucleoside analog drug discovery.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of advanced nucleoside analog drugs targeting viral infections and oncology.
• Antiviral Drug Research: Used in the R&D of novel therapeutics for viruses such as hepatitis, influenza, and herpes, leveraging the fluorine atom for improved efficacy.
• Anticancer Agent Development: Serves as a precursor in creating chemotherapeutic agents that interfere with DNA/RNA synthesis in rapidly dividing cancer cells.
• Biochemical Research: Employed in academic and industrial research to study enzyme inhibition, metabolic pathways, and structure-activity relationships (SAR).
• Process Chemistry & Scale-Up: Supplied to CROs and CDMOs for process development, optimization, and commercial-scale GMP manufacturing of APIs.

Basic Information

Item	Details
Product Name	2,5-Anhydro-3-Deoxy-3-(5-Fluoro-3,4-Dihydro-2,4-Dioxo-1(2H)-Pyrimidinyl)-D-Mannitol
CAS No.	302790-83-6
Molecular Formula	C10H12FN2O6
Molecular Weight	275.21 g/mol
Synonyms	5-Fluoro-1-(2,5-anhydro-3-deoxy-D-mannitol-3-yl)pyrimidine-2,4(1H,3H)-dione; 3'-Deoxy-3'-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-anhydro-D-mannitol; 5-Fluoro-1-(2,5-anhydro-3-deoxy-D-mannofuranos-3-yl)uracil; 5-Fluoro-1-(2,5-anhydro-3-deoxy-β-D-mannofuranosyl)uracil; Fluorinated D-mannitol nucleoside analog; 302790-83-6; 1-(2,5-Anhydro-3-deoxy-β-D-mannofuranosyl)-5-fluorouracil
EINECS	Contact for details

Quality Control

Every batch of 2,5-Anhydro-3-Deoxy-3-(5-Fluoro-3,4-Dihydro-2,4-Dioxo-1(2H)-Pyrimidinyl)-D-Mannitol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to support research and GMP-grade applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality standards are designed to meet the rigorous demands of pharmaceutical development and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under dry conditions to prevent decomposition. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.