Description

n-[6-Chloro-5-(2-Methoxyphenoxy)[2,2'-Bipyrimidin]-4-Yl]-4-(1,1-Dimethylethyl)Benzenesulfonamide Potassium Salt is a high-purity, non-racemic synthetic intermediate of significant importance in advanced pharmaceutical research and development. Its complex bipyrimidine-sulfonamide structure makes it a critical building block for the synthesis of novel, targeted therapeutic agents. This compound is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of investigational new drugs, particularly in oncology and anti-inflammatory research.
• Kinase Inhibitor Development: Serves as a core scaffold or advanced intermediate for creating potent and selective kinase inhibitors, targeting specific enzymatic pathways.
• Chemical Biology Research: Used as a tool compound or probe in biochemical assays to study protein-ligand interactions and signal transduction mechanisms.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production for new active pharmaceutical ingredients (APIs).
• Reference Standard: Utilized as a high-purity analytical standard for method development and quality control in regulatory filings.
• Custom Synthesis & Contract Manufacturing: A starting material for the custom synthesis of specialized derivatives and analogs for client-specific research programs.

Basic Information

Product Name	n-[6-Chloro-5-(2-Methoxyphenoxy)[2,2'-Bipyrimidin]-4-Yl]-4-(1,1-Dimethylethyl)Benzenesulfonamide Potassium Salt
CAS No.	301646-59-3
Molecular Formula	C27H25ClKN5O4S
Molecular Weight	598.13 g/mol
Synonyms	4-tert-Butyl-N-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide potassium salt; Bipyrimidine Sulfonamide Potassium Salt; Potassium 4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide; 301646-59-3; 4-(tert-Butyl)-N-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide potassium salt; Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-, potassium salt
EINECS	Contact for details

Quality Control

Our n-[6-Chloro-5-(2-Methoxyphenoxy)[2,2'-Bipyrimidin]-4-Yl]-4-(1,1-Dimethylethyl)Benzenesulfonamide Potassium Salt is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.