Description

Boc-Thr(Allyl)-Oh CAS NO 300831-37-2 is a protected amino acid derivative, specifically N-tert-Butoxycarbonyl-O-allyl-L-threonine, serving as a critical building block in peptide synthesis. Its value lies in providing orthogonal protection for the threonine side chain, enabling complex, multi-step solid-phase and solution-phase peptide assembly with high selectivity. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of threonine residues with protected side-chain functionality.
• Solution-Phase Peptide Chemistry: Used in the synthesis of complex peptide sequences and cyclic peptides where selective deprotection is required.
• Pharmaceutical Intermediate: Serves as a vital raw material in the research and development of peptide drugs, including hormones, antibiotics, and enzyme inhibitors.
• Glycopeptide Synthesis: The allyl-protected hydroxyl group allows for further chemical modification, making it a precursor for synthesizing glycopeptides.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for drug discovery and high-throughput screening.
• Bioconjugation: Acts as a linker or spacer molecule in the conjugation of peptides to other biomolecules, polymers, or surfaces.

Basic Information

Product Name	Boc-Thr(Allyl)-Oh
CAS No.	300831-37-2
Molecular Formula	C₁₂H₂₁NO₅
Molecular Weight	259.30 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-O-allyl-L-threonine; Boc-O-allyl-L-threonine; (2S,3R)-2-[(tert-Butoxycarbonyl)amino]-3-(allyloxy)butanoic acid; tert-Butyl (2S,3R)-2-amino-3-(allyloxy)butanoate; Boc-L-Thr(All)-OH; Boc-Thr(All)-OH; N-Boc-O-allylthreonine; Boc-Threonine(O-allyl)
EINECS	Contact for details

Quality Control

Our Boc-Thr(Allyl)-Oh is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Specific Impurities (HPLC)	Individual unknown ≤0.5%; Total impurities ≤2.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.