Description

L-Threonine Ethyl Ester Hydrochloride is a protected derivative of the essential amino acid L-Threonine, widely utilized as a key chiral building block in organic synthesis. This high-purity intermediate is critical for ensuring the stereochemical integrity and yield of complex target molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and peptide synthesis industries for the development of active pharmaceutical ingredients (APIs), bioactive peptides, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the asymmetric synthesis of novel therapeutic compounds and Active Pharmaceutical Ingredients (APIs).
• Peptide Synthesis: Serves as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis for research and production.
• Biochemical Research: Used as a standard or reagent in metabolic studies, enzyme substrate research, and biochemical pathway analysis.
• Agrochemical Development: Employed in the synthesis of chiral herbicides, fungicides, and other agrichemicals where specific stereochemistry is required for activity.
• Fine Chemical Production: Acts as a building block for synthesizing complex molecules used in flavors, fragrances, and advanced materials.
• Protecting Group Strategy: The ethyl ester and hydrochloride salt provide stability and handling advantages during multi-step synthetic sequences.

Basic Information

Product Name	L-Threonine Ethyl Ester Hydrochloride
CAS No.	39994-70-2
Molecular Formula	C6H14ClNO3
Molecular Weight	183.63 g/mol
Synonyms	L-Threonine Ethyl Ester HCl; (2S,3R)-2-Amino-3-hydroxybutyric Acid Ethyl Ester Hydrochloride; Ethyl L-Threoninate Hydrochloride; H-Thr-OEt·HCl; Threonine Ethyl Ester Hydrochloride; (S)-Threonine Ethyl Ester Hydrochloride; L-2-Amino-3-hydroxybutyric Acid Ethyl Ester Hydrochloride
EINECS	Contact for details

Quality Control

Our L-Threonine Ethyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing specific results for identity, assay, optical rotation, and impurity profiles is provided with every shipment to guarantee consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Optical Rotation [α]20/D	-5.0° to -7.0° (c=1 in H2O)
Chiral Purity (HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.