Description

n-Acetyl-L-Hydroxyproline is a chemically modified derivative of the amino acid L-hydroxyproline, featuring an acetyl group that enhances its stability and alters its physicochemical properties. This modification makes it a valuable chiral building block and intermediate in sophisticated organic synthesis, particularly for pharmaceutical research and development. It is essential for industries focused on producing peptides, active pharmaceutical ingredients (APIs), and other fine chemicals where precise stereochemistry and functional group compatibility are critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide chemistry.
• Biochemical Research: Serves as a standard or reagent in metabolic studies and enzymatic research related to collagen and protein modification.
• Cosmetic & Dermatological Actives: Incorporated into formulations targeting skin conditioning and anti-aging, leveraging its proline derivative properties.
• Asymmetric Catalysis: Employed as a ligand or precursor in catalytic systems requiring specific chiral environments.
• Food & Flavor Industry: Potential use as a precursor for flavor enhancers or in the synthesis of specialty food ingredients.

Basic Information

Product Name	n-Acetyl-L-Hydroxyproline
CAS No.	39966-33-7
Molecular Formula	C7H11NO4
Molecular Weight	173.17 g/mol
Synonyms	N-Acetyl-L-hydroxyproline; (2S,4R)-1-Acetyl-4-hydroxypyrrolidine-2-carboxylic acid; Ac-Hyp-OH; L-4-Hydroxyproline, N-acetyl-; N-Acetyl-4-hydroxy-L-proline; N-Acetyl-trans-4-hydroxy-L-proline; 1-Acetyl-4-hydroxy-L-proline; trans-4-Hydroxy-N-acetyl-L-proline
EINECS	Contact for details

Quality Control

Our n-Acetyl-L-Hydroxyproline is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for research and industrial applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-70° to -80° (c=1 in H2O)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.