Description

(D-Leu2)-Melanocyte-Stimulating Hormone-Release Inhibiting Factor CAS NO 39705-60-7 is a synthetic peptide analog of the endogenous neuropeptide MIF-1 (Melanocyte-Stimulating Hormone Release-Inhibiting Factor). This compound is significant for its role in modulating melanocyte-stimulating hormone (MSH) activity and has been a valuable tool in neuroendocrine and dermatological research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies investigating peptide therapeutics, skin pigmentation disorders, and central nervous system functions.

Application

• Neuroendocrine Research: Used as a reference standard and active agent in studies of MSH release inhibition and related hypothalamic-pituitary functions.
• Dermatological R&D: Investigated for its potential effects on melanogenesis and as a lead compound in developing treatments for pigmentation disorders.
• Pharmacological Studies: Serves as a key reagent in receptor binding assays and functional studies to understand peptide hormone signaling pathways.
• Biochemical Tool: Employed in the development and validation of analytical methods, such as HPLC and mass spectrometry, for peptide quantification.
• Neuroscience Research: Explored for its behavioral and neurological effects in preclinical models, contributing to the understanding of peptide-brain interactions.
• Peptide Chemistry Reference: Used as a high-purity building block or intermediate in the synthesis of more complex peptide analogs.

Basic Information

Item	Detail
Product Name	(D-Leu2)-Melanocyte-Stimulating Hormone-Release Inhibiting Factor
CAS No.	39705-60-7
Molecular Formula	C₂₀H₃₂N₆O₄
Molecular Weight	420.51 g/mol
Synonyms	(D-Leu2)-MIF-1; D-Leucyl-MIF-1; Prolyl-leucyl-glycinamide, 1-(3-mercaptopropanoic acid)-; Melanostatin (D-Leu2) analog; MSH Release-Inhibiting Factor (D-Leu2); Tyr-Pro-D-Leu-Gly-NH2; L-Tyrosyl-L-prolyl-D-leucylglycinamide; 39705-60-7
EINECS	Contact for details

Quality Control

Our (D-Leu2)-Melanocyte-Stimulating Hormone-Release Inhibiting Factor is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This hygroscopic (moisture-sensitive) material should be kept in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to theoretical values
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.