Description

5-Methyltetrahydropteroylpentaglutamate is a complex folate derivative, specifically a pentaglutamate form of 5-methyltetrahydrofolate. This compound is of significant interest in advanced biochemical research and pharmaceutical development due to its role as a key intracellular folate metabolite and polyglutamated cofactor. It is primarily utilized by research institutions, diagnostic manufacturers, and pharmaceutical companies engaged in metabolic pathway studies, enzyme kinetics, and the development of novel therapeutic agents targeting folate-dependent processes.

Application

• Biochemical Research: Serves as a critical substrate and reference standard for studying enzymes like folylpolyglutamate synthetase and γ-glutamyl hydrolase.
• Pharmaceutical Development: Used in the research and development of drugs targeting folate metabolism, including potential anticancer and antimicrobial agents.
• Diagnostic Reagents: Acts as a key component in the formulation of high-sensitivity diagnostic assays for measuring folate status and related enzymatic activities in clinical samples.
• Metabolic Studies: Essential for in vitro and cellular studies investigating one-carbon metabolism, nucleotide synthesis, and methylation cycles.
• Enzyme Characterization: Employed as a specific ligand or inhibitor in the purification and functional characterization of folate-binding proteins and receptors.
• Nutritional Science Research: Used as a refined tool to study the bioavailability and cellular processing of complex dietary folates.

Basic Information

Product Name	5-Methyltetrahydropteroylpentaglutamate
CAS No.	39555-46-9
Molecular Formula	C₃₅H₄₈N₁₀O₁₇
Molecular Weight	904.83 g/mol
Synonyms	5-Methyltetrahydrofolylpentaglutamate; 5-Methyl-THPteGlu5; 5-CH3-H4PteGlu5; (6S)-5-Methyl-5,6,7,8-tetrahydrofolic acid pentaglutamate; 5-Methyl-5,6,7,8-tetrahydropteroyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamic acid; 5-Methyltetrahydrofolate pentaglutamate; 5-MTHF-Glu5
EINECS	Contact for details

Quality Control

Our 5-Methyltetrahydropteroylpentaglutamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and related substance profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under inert atmosphere when possible and allowed to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC/UV)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 90.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Soluble in basic aqueous solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.