Description

Ddz-Cyss(Tbu)-Oh Dcha is a protected cysteine derivative widely used as a key building block in peptide synthesis. This compound matters for its role in introducing cysteine residues into peptide chains while preventing unwanted side reactions during the assembly process. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the production of therapeutic peptides, research peptides, and complex organic molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical reagent for the controlled incorporation of cysteine, enabling the formation of disulfide bridges in synthetic peptides.
• Pharmaceutical Intermediate: Serves as a key raw material in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation Chemistry: Used to introduce thiol-reactive handles onto biomolecules for labeling, drug-antibody conjugation (ADC), or surface modification.
• Research & Development: Essential for academic and industrial research in biochemistry, molecular biology, and medicinal chemistry for studying protein structure and function.
• Custom Peptide Production: A fundamental component in the toolkit of CROs and CDMOs offering custom peptide synthesis services.
• Protecting Group Strategy: The Ddz (2,4-Dimethoxybenzyl) and Tbu (tert-Butyl) groups provide orthogonal protection for the amine and thiol functionalities, respectively.

Basic Information

Product Name	Ddz-Cyss(Tbu)-Oh Dcha
CAS No.	39508-12-8
Molecular Formula	C24H40N2O5S
Molecular Weight	468.65 g/mol
Synonyms	N-α-(2,4-Dimethoxybenzyl)-S-tert-butyl-L-cysteine Dicyclohexylammonium Salt; Ddz-Cys(Tbu)-OH·DCHA; N-Ddz-S-tert-butyl-L-cysteine DCHA salt; Fmoc-Cys(Trt)-OH (Note: This is a different, more common protecting group combination); N-2,4-Dimethoxybenzyl-S-tert-butylcysteine Dicyclohexylamine Salt; L-Cysteine, N-[(2,4-dimethoxyphenyl)methyl]-S-(1,1-dimethylethyl)-, compd. with N-cyclohexylcyclohexanamine (1:1); Protected Cysteine Derivative DCHA Salt.
EINECS	Contact for details

Quality Control

Our Ddz-Cyss(Tbu)-Oh Dcha is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.