Description

Angiotensin II, Des-Phe(8)- is a specific, biologically active peptide fragment derived from the renin-angiotensin system. This compound is a critical research tool for studying angiotensin receptor activity, signal transduction pathways, and cardiovascular physiology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic manufacturers focused on hypertension, heart failure, and metabolic disorders.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of the renin-angiotensin-aldosterone system (RAAS).
• Pharmacological Assays: Serves as a key ligand in receptor binding studies and functional assays for angiotensin receptor subtypes (e.g., AT1, AT2).
• Drug Discovery & Development: Employed in high-throughput screening (HTS) to identify and characterize novel angiotensin receptor modulators and inhibitors.
• Diagnostic Development: Acts as a critical component in the development and calibration of immunoassays and biosensors for cardiovascular biomarkers.
• Biochemical Studies: Utilized to investigate peptide metabolism, enzyme kinetics (e.g., with angiotensin-converting enzyme), and downstream cellular signaling events.
• Academic & Clinical Research: Fundamental for exploring the pathophysiological roles of angiotensin peptides in hypertension, renal function, and vascular biology.

Basic Information

Product Name	Angiotensin II, Des-Phe(8)-
CAS No.	39386-80-6
Molecular Formula	C41H62N12O10
Molecular Weight	883.0 g/mol
Synonyms	Angiotensin II (1-7); Asp-Arg-Val-Tyr-Ile-His-Pro; [Des-Phe8]-Angiotensin II; Ang-(1-7); H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH; DRVYIHP; CAS 51833-78-4 (often associated)
EINECS	Contact for details

Quality Control

Our Angiotensin II, Des-Phe(8)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (typically ≥95% to ≥98%), to ensure consistency and reliability for critical research applications. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥95.0%
Peptide Content (UV)	≥80.0%
Water Content (KF)	≤5.0%
Acetate Content (HPLC)	≤10.0%
Solubility	Soluble in water, aqueous acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.