Description

Ac-His-Oh H2O is a high-purity, protected derivative of the amino acid L-Histidine, specifically the Nα-acetylated form. This compound is a critical building block in peptide synthesis and biochemical research, offering enhanced stability and solubility for advanced applications. It is essential for pharmaceutical R&D, biotechnology, and academic laboratories focused on developing novel peptide-based therapeutics and diagnostic tools.

Application

• Peptide Synthesis: A key protected amino acid for solid-phase and solution-phase synthesis of complex peptides and proteins.
• Pharmaceutical Intermediates: Serves as a crucial intermediate in the development of active pharmaceutical ingredients (APIs) with histidine motifs.
• Biochemical Research: Used as a standard or reagent in enzymatic studies, metabolic pathway analysis, and protein structure-function research.
• Cell Culture Media: A component in specialized cell culture formulations and nutrient media for sensitive biological studies.
• Diagnostic Reagent Manufacturing: Employed in the production of reagents and kits for clinical diagnostics and immunoassays.

Basic Information

Item	Detail
Product Name	Ac-His-Oh H2O
CAS No.	39145-52-3
Molecular Formula	C8H13N3O4 • xH2O
Molecular Weight	215.21 (Anhydrous basis)
Synonyms	Nα-Acetyl-L-histidine; Ac-L-His-OH; Acetylhistidine; N-Acetyl-L-histidine; N-Acetylhistidine; L-Histidine, N-acetyl-; (2S)-2-Acetamido-3-(1H-imidazol-4-yl)propanoic acid; Ac-His-OH hydrate
EINECS	Contact for details

Quality Control

Our Ac-His-Oh H2O is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-20.0° to -25.0° (c=1 in H2O)
Water Content (KF)	≤10.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.