Description

4-(Chloro-Difluoro-Methoxy)-Phenylamine is a specialized aromatic amine derivative featuring a chloro-difluoro-methoxy substituent. This compound is a high-value intermediate prized for its unique halogenated ether-amine structure, which imparts specific electronic and steric properties. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly where the introduction of fluorinated motifs is critical for enhancing metabolic stability, bioavailability, or binding affinity.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug candidates, especially in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the production of specialty chemicals for electronic displays, leveraging its aromatic amine core for charge transport materials.
• Polymer Modification: Employed as a functional monomer or cross-linking agent to introduce amine and halogenated ether groups into polymer chains, altering material properties.
• Organic Synthesis & Catalysis: Acts as a versatile reagent or ligand precursor in complex organic transformations and catalytic systems in academic and industrial R&D.

Basic Information

Product Name	4-(Chloro-Difluoro-Methoxy)-Phenylamine
CAS No.	39065-95-7
Molecular Formula	C7H6ClF2NO
Molecular Weight	193.58 g/mol
Synonyms	4-Amino-2-chloro-α,α-difluoroanisole; 1-Amino-4-(chlorodifluoromethoxy)benzene; Benzenamine, 4-(chlorodifluoromethoxy)-; 4-(Chlorodifluoromethoxy)aniline; 2-Chloro-α,α-difluoro-p-anisidine; p-(Chlorodifluoromethoxy)aniline; 4-(ClF2CO)C6H4NH2; 39065-95-7
EINECS	Contact for details

Quality Control

Our 4-(Chloro-Difluoro-Methoxy)-Phenylamine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most sensitive synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions. For long-term storage, consider an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.