Description

4-Amino-1-[(2R)-Tetrahydro-5β-Hydroxy-2H-Pyran-2-Yl]Pyrimidin-2(1H)-One is a high-purity nucleoside analog building block of significant importance in advanced pharmaceutical synthesis. This compound serves as a critical intermediate for the development of novel antiviral and anticancer therapeutics, where precise stereochemistry and purity are paramount. It is essential for research institutions and pharmaceutical manufacturers engaged in nucleoside chemistry, medicinal chemistry, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex nucleoside-based antiviral and anticancer drugs.
• Medicinal Chemistry Research: Used in R&D for structure-activity relationship (SAR) studies and the discovery of new therapeutic agents targeting viral polymerases.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the multi-step synthesis of final drug substances requiring high stereochemical fidelity.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and DNA/RNA synthesis.
• Process Development: Utilized in scaling up and optimizing synthetic routes for commercial pharmaceutical manufacturing.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	4-Amino-1-[(2R)-Tetrahydro-5β-Hydroxy-2H-Pyran-2-Yl]Pyrimidin-2(1H)-One
CAS No.	39057-02-8
Molecular Formula	C9H13N3O3
Molecular Weight	211.22 g/mol
Synonyms	4-Amino-1-[(2R)-tetrahydro-5β-hydroxy-2H-pyran-2-yl]-2(1H)-pyrimidinone; (2R,5S)-5-Hydroxy-1-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)tetrahydro-2H-pyran-2-carbaldehyde (tautomer); 4-Amino-1-((2R,5S)-5-hydroxy-tetrahydro-2H-pyran-2-yl)pyrimidin-2(1H)-one; Nucleoside analog intermediate; 1-(5-Hydroxy-tetrahydro-pyran-2-yl)-4-amino-1H-pyrimidin-2-one; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 4-Amino-1-[(2R)-Tetrahydro-5β-Hydroxy-2H-Pyran-2-Yl]Pyrimidin-2(1H)-One is manufactured under strict quality systems. Products undergo rigorous analytical testing, including chiral HPLC, to ensure high chemical and stereochemical purity suitable for pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with each batch to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.