Description

(+/-)-1-Aminocyclopentane-cis-1,2-Dicarboxylic Acid CAS NO 39026-64-7 is a conformationally constrained dicarboxylic acid derivative that serves as a key chiral building block and a potent, selective pharmacological agent. This compound matters for its role as a competitive antagonist at group II metabotropic glutamate receptors (mGluR2/3), making it a critical tool in neuroscience research for studying synaptic transmission and neurological disorders. It is primarily needed by pharmaceutical R&D teams, academic neuroscientists, and fine chemical manufacturers developing novel central nervous system (CNS) therapeutics and advanced intermediates.

Application

• Neuroscience Research: As a selective group II mGluR antagonist for in vitro and in vivo studies of synaptic plasticity, anxiety, and psychosis.
• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel neuroactive compounds and potential drug candidates targeting glutamate pathways.
• Biochemical Tool Compound: Used in high-throughput screening (HTS) assays to identify and validate new modulators of metabotropic glutamate receptors.
• Reference Standard: Serves as an analytical standard in pharmacokinetic and metabolic studies for related investigational new drugs.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to design molecules with improved potency and selectivity for neurological targets.

Basic Information

Product Name	(+/-)-1-Aminocyclopentane-cis-1,2-Dicarboxylic Acid
CAS No.	39026-64-7
Molecular Formula	C7H11NO4
Molecular Weight	173.17 g/mol
Synonyms	(±)-1-Aminocyclopentane-cis-1,2-dicarboxylic Acid; (±)-ACPD; cis-1-Aminocyclopentane-1,3-dicarboxylic Acid; (±)-cis-1-Aminocyclopentane-1,3-dicarboxylic Acid; (±)-1-Aminocyclopentane-1,3-dicarboxylic Acid; (RS)-1-Aminocyclopentane-cis-1,2-dicarboxylic Acid; ACPD; mGluR Group II Antagonist
EINECS	Contact for details

Quality Control

Our (+/-)-1-Aminocyclopentane-cis-1,2-Dicarboxylic Acid is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for fine chemicals and can provide material suitable for advanced pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.