Description

n-(4-Iodobenzoyl)-L-Glutamic Acid is a specialized iodinated aromatic amino acid derivative that serves as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of targeted pharmaceuticals and diagnostic agents, particularly where precise molecular architecture is required. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel bioactive molecules, including potential enzyme inhibitors and radiopharmaceutical precursors.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of targeted therapeutic agents and enzyme inhibitors.
• Radiopharmaceutical Research: Serves as a starting material for iodine-123 or iodine-131 labeled compounds used in diagnostic imaging.
• Bioconjugation Chemistry: Used in the development of antibody-drug conjugates (ADCs) and other targeted delivery systems.
• Peptidomimetic Synthesis: Integral building block for creating modified peptides with enhanced stability or binding affinity.
• Chemical Biology Probes: Employed in the design of activity-based probes for studying enzyme function and protein interactions.
• Academic & Industrial R&D: Utilized in exploratory research for new chemical entities across medicinal chemistry and drug discovery programs.

Basic Information

Product Name	n-(4-Iodobenzoyl)-L-Glutamic Acid
CAS No.	38974-68-4
Molecular Formula	C12H12INO6
Molecular Weight	401.13 g/mol
Synonyms	N-(4-Iodobenzoyl)glutamic acid; L-Glutamic acid, N-(4-iodobenzoyl)-; (2S)-2-[(4-Iodobenzoyl)amino]pentanedioic acid; 4-Iodobenzoyl-L-glutamic acid; N-(p-Iodobenzoyl)-L-glutamic acid; PGA-I; Iodobenzoylglutamate
EINECS	Contact for details

Quality Control

Our n-(4-Iodobenzoyl)-L-Glutamic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Specific range available on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.