Description

4-o-(2-Amino-2-Deoxy-α-D-Glucopyranosyl)-5-o-[3-o-(2,6-Diamino-2,6-Dideoxy-β-L-Idopyranosyl)-β-D-Ribofuranosyl]-D-Streptamine CAS NO 38965-79-6 is a structurally complex aminoglycoside antibiotic intermediate. This compound is of critical importance for the research and development of novel antibacterial agents and for studying mechanisms of antibiotic resistance. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in medicinal chemistry and microbiology. Its precise structure makes it a valuable building block for synthesizing and modifying advanced therapeutic candidates.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of novel aminoglycoside antibiotics and semi-synthetic derivatives.
• Mechanistic Studies: Used in biochemical research to investigate bacterial ribosome binding, antibiotic action, and resistance pathways.
• Medicinal Chemistry: Acts as a scaffold for structure-activity relationship (SAR) studies to optimize antimicrobial potency and reduce toxicity.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Bioconjugation & Prodrug Development: Utilized in creating targeted antibiotic delivery systems or prodrug formulations.
• Academic Research: Fundamental tool for teaching and advanced research in organic chemistry, carbohydrate chemistry, and pharmacology.

Basic Information

Item	Details
Product Name	4-o-(2-Amino-2-Deoxy-α-D-Glucopyranosyl)-5-o-[3-o-(2,6-Diamino-2,6-Dideoxy-β-L-Idopyranosyl)-β-D-Ribofuranosyl]-D-Streptamine
CAS No.	38965-79-6
Molecular Formula	C26H48N6O16
Molecular Weight	676.69 g/mol
Synonyms	4-O-(2-Amino-2-deoxy-α-D-glucopyranosyl)-5-O-[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-β-D-ribofuranosyl]-D-streptamine; Antibiotic G-418 Intermediate; Geneticin Intermediate; G418 Aminoglycoside Core; 2-Deoxystreptamine Derivative; 4,5-Disubstituted Streptamine; 3'-Deoxyparomamine Derivative; Nebramycin Factor 5' Precursor
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for research and development applications. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and Mass Spectrometry to ensure structural identity and high purity. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with each shipment. We support compliance with cGMP guidelines for API intermediate manufacturing upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a desiccated environment. For long-term storage, consider inert atmosphere packaging to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.