Description

H-D-Leu-Leu-Oh CAS NO 38689-31-5 is a high-purity, protected dipeptide building block, specifically the C-terminal carboxylic acid form of H-D-Leu-Leu. This compound is a critical intermediate in the synthesis of more complex peptides and peptidomimetics, offering precise stereochemical control for advanced research and development. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic institutions focused on drug discovery, proteomics, and biochemical studies. Its defined structure ensures reliable and reproducible results in synthetic pathways.

Application

• Pharmaceutical Research & Development: A key building block for the solid-phase and solution-phase synthesis of novel therapeutic peptides and peptidomimetics targeting various diseases.
• Protease Inhibitor Design: Used in the development of specific inhibitors for leucine-specific proteases due to its D-Leu-L-Leu sequence, which can mimic natural substrates.
• Biochemical Tool Compound: Serves as a standard or substrate in enzymatic assays to study protease activity, specificity, and inhibition kinetics.
• Academic & Institutional Research: Employed in universities and research institutes for fundamental studies in peptide chemistry, molecular recognition, and structural biology.
• Custom Peptide Synthesis Services: A fundamental raw material for CROs and CDMOs offering bespoke peptide manufacturing for clients worldwide.
• Chemical Biology Probes: Incorporated into larger constructs to create probes for labeling, imaging, or modulating biological processes within cells.

Basic Information

Product Name	H-D-Leu-Leu-Oh
CAS No.	38689-31-5
Molecular Formula	C12H24N2O3
Molecular Weight	244.33 g/mol
Synonyms	H-D-Leu-L-Leu-OH; (2R)-2-[[(2S)-2-Amino-4-methylpentanoyl]amino]-4-methylpentanoic acid; D-Leucyl-L-leucine; D-Leu-L-Leu; Boc-D-Leu-L-Leu-OH (protected analog); Fmoc-D-Leu-L-Leu-OH (protected analog); D-Leucine-L-leucine; N-[(2S)-2-Amino-4-methylpentanoyl]-D-leucine
EINECS	Contact for details

Quality Control

Every batch of H-D-Leu-Leu-Oh is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive research and development applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (HPLC), chiral purity, and residual solvent content. Our quality commitment supports compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de (D-Leu, L-Leu)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.