Description

H-Phe-Trp-Nh2 Hcl is a high-purity, protected dipeptide derivative used as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise molecular scaffolds for developing novel bioactive molecules. It is primarily utilized in pharmaceutical R&D for peptide-based drug discovery, as well as in biochemical studies investigating enzyme-substrate interactions and signal transduction pathways.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics for therapeutic applications.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic assays and studies related to protease activity and peptide metabolism.
• Drug Discovery: Acts as a core structural element in medicinal chemistry programs targeting GPCRs, kinases, and other protein targets.
• Neuroscience Research: Employed in the study of neuropeptides and their analogs due to the presence of the tryptophan and phenylalanine residues.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	H-Phe-Trp-Nh2 Hcl
CAS No.	38678-69-2
Molecular Formula	C21H23N4O2 • HCl
Molecular Weight	408.90 g/mol (free base: 372.44 g/mol)
Synonyms	L-Phenylalanyl-L-tryptophanamide hydrochloride; Phe-Trp-NH2 • HCl; F-W-NH2 hydrochloride; H-Phe-Trp-NH2 hydrochloride; N-(Benzyloxycarbonyl)-L-phenylalanyl-L-tryptophanamide HCl; Z-Phe-Trp-NH2 HCl (protected form); L-Phe-L-Trp-NH2 • HCl; Phenylalanine-tryptophan amide hydrochloride
EINECS	Contact for details

Quality Control

Our H-Phe-Trp-Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets rigorous research and development standards. Certificates of Analysis (COA) with complete chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay (Titration)	97.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.