Description

H-Phe-Ser-Nh2 Hcl is a protected dipeptide derivative, specifically the hydrochloride salt of L-Phenylalanyl-L-serinamide. This compound serves as a crucial building block (synthon) in advanced organic synthesis, particularly for constructing complex peptide sequences with high stereochemical purity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of therapeutic peptides, prodrugs, and bioactive molecules.

Application

• Pharmaceutical Intermediate: Key raw material for the synthesis of novel therapeutic peptides and peptidomimetics.
• Biochemical Research: Used as a substrate or standard in enzymatic studies and proteomics research.
• Solid-Phase Peptide Synthesis (SPPS): An essential protected amino acid derivative for the sequential assembly of custom peptides.
• Combinatorial Chemistry: Building block for creating diverse chemical libraries for high-throughput screening in drug discovery.
• Cosmetic Peptide Synthesis: Intermediate in the production of bioactive peptides for advanced skincare formulations.

Basic Information

Product Name	H-Phe-Ser-Nh2 Hcl
CAS No.	38678-66-9
Molecular Formula	C12H18N3O3·HCl
Molecular Weight	289.75 g/mol
Synonyms	L-Phenylalanyl-L-serinamide hydrochloride; F-Ser-NH2·HCl; H-Phe-Ser-NH2·HCl; Phe-Ser-NH2 hydrochloride; N-(Benzyloxycarbonyl)-L-phenylalanyl-L-serinamide HCl; Z-Phe-Ser-NH2 HCl (common protected form precursor); (2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-hydroxypropanamide hydrochloride
EINECS	Contact for details

Quality Control

Our H-Phe-Ser-Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed HPLC chromatograms and impurity profiles, supporting compliance with cGMP and ICH Q7 guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.