Description

(His(1-Me)2)-LHRH is a synthetic peptide analog of Gonadotropin-Releasing Hormone (GnRH), a key regulator of the reproductive endocrine system. This modified compound is engineered for enhanced stability and targeted biological activity, making it a critical intermediate in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in developing novel therapeutics for endocrinology, oncology, and reproductive medicine.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced GnRH agonist or antagonist drug candidates.
• Endocrine Research: Used in biochemical and pharmacological studies to investigate the hypothalamic-pituitary-gonadal axis and hormone regulation mechanisms.
• Oncology Research: Applied in the development of targeted therapies for hormone-dependent cancers, such as prostate and breast cancer.
• Veterinary Medicine: Employed in research for developing fertility control and reproductive management solutions in animals.
• Peptide Chemistry Studies: Acts as a model compound for studying structure-activity relationships (SAR) and peptide modification techniques.
• Diagnostic Development: Potential use in the development of immunoassays and diagnostic tools for reproductive disorders.

Basic Information

Product Name	(His(1-Me)2)-LHRH
CAS No.	38343-57-6
Molecular Formula	C64H88N18O13
Molecular Weight	1293.5 g/mol
Synonyms	Histidyl(1-methyl)-LHRH; [His(1-Me)2]-Luteinizing Hormone-Releasing Hormone; Modified GnRH analog; Gonadorelin analog; LHRH (1-Me-His2) derivative; pGlu-His(1-Me)-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2; 38343-57-6
EINECS	Contact for details

Quality Control

Our (His(1-Me)2)-LHRH is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, peptide content, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.