Description

2-Thioltryptophan is a specialized sulfur-containing derivative of the essential amino acid tryptophan, identified by CAS NO 38327-45-6. This compound is of significant interest in advanced biochemical research and pharmaceutical development due to its unique thiol functional group, which can serve as a reactive handle for conjugation or as a modulator of redox activity. It is primarily utilized by researchers and manufacturers in the fields of peptide synthesis, proteomics, and medicinal chemistry, where it is employed to study protein structure-function relationships, develop novel enzyme inhibitors, or create targeted bioconjugates.

Application

• Pharmaceutical Intermediate: Used in the research and synthesis of novel drug candidates, particularly those targeting neurological pathways or requiring specific redox properties.
• Biochemical Research Reagent: Serves as a critical building block in peptide synthesis for introducing thiol groups, enabling site-specific modifications and cross-linking studies.
• Proteomics and Enzyme Studies: Employed to investigate enzyme mechanisms, protein folding, and as a potential active site probe for cysteine proteases and other thiol-dependent enzymes.
• Conjugation Chemistry: The thiol group facilitates conjugation with maleimides, halogens, or other electrophiles, making it valuable for creating antibody-drug conjugates (ADCs) or fluorescent probes.
• Nutritional Science Research: Studied for its potential metabolic role as a modified amino acid, though primarily in an investigational context.

Basic Information

Product Name	2-Thioltryptophan
CAS No.	38327-45-6
Molecular Formula	C11H12N2O2S
Molecular Weight	236.29 g/mol
Synonyms	2-Mercaptotryptophan; Tryptophan, 2-mercapto-; 2-Thio-L-tryptophan; L-Tryptophan, 2-mercapto-; 2-SH-Trp; 2-Thiol-L-tryptophan; 2-Mercapto-L-tryptophan; α-Amino-1H-indole-3-propanoic acid, 2-mercapto-
EINECS	Contact for details

Quality Control

Our 2-Thioltryptophan is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing results from HPLC for assay and purity, chiral analysis, and residual solvent testing. We adhere to high-purity standards suitable for research and development applications, with specifications tailored to meet the demanding requirements of pharmaceutical and biochemical clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, consider under an inert atmosphere such as argon or nitrogen. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.