Description

Methyl 2-Methanesulfonylpyrimidine-5-Carboxylate is a high-purity, synthetically valuable pyrimidine derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate) for the development of novel therapeutic agents. Its unique structure, featuring both a methanesulfonyl and a carboxylate ester group, makes it a versatile building block for constructing complex molecular architectures. This compound is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams focused on creating targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators due to its pyrimidine core.
• Material Science: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers and advanced organic materials.
• Chemical Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic substitutions, and other transformations to introduce the 2-methanesulfonylpyrimidine moiety.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) laboratories for medicinal chemistry programs and novel compound library generation.

Basic Information

Product Name	Methyl 2-Methanesulfonylpyrimidine-5-Carboxylate
CAS No.	38275-49-9
Molecular Formula	C8H10N2O4S
Molecular Weight	230.24 g/mol
Synonyms	Methyl 2-(methylsulfonyl)pyrimidine-5-carboxylate; 5-Pyrimidinecarboxylic acid, 2-(methylsulfonyl)-, methyl ester; 2-Methanesulfonyl-pyrimidine-5-carboxylic acid methyl ester; Methyl 2-methylsulfonylpyrimidine-5-carboxylate; 2-(Methylsulfonyl)pyrimidine-5-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Methanesulfonylpyrimidine-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chemical purity and consistency, meeting the stringent requirements for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.