Description

Glycine, n-[(2-Chloro-1,1-Dimethylethoxy)Carbonyl]- (9Ci) is a specialized amino acid derivative featuring a chloro-tert-butoxycarbonyl (Cl-t-Boc) protecting group. This compound is a critical building block in peptide synthesis and organic chemistry, valued for its role in introducing and protecting the glycine moiety under specific reaction conditions. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel peptides, APIs, and fine chemicals. Its precise structure offers controlled reactivity, making it essential for complex multi-step synthetic routes.

Application

• Peptide Synthesis: Serves as a key protected glycine derivative in solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Intermediates: Used in the research and production of active pharmaceutical ingredients (APIs) and drug candidates.
• Organic Synthesis Building Block: Acts as a versatile reagent for introducing the glycine fragment into complex organic molecules.
• Bioconjugation Chemistry: Employed in the modification of biomolecules where a protected amino acid linker is required.
• Chemical Research & Development: Utilized in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries.
• Protecting Group Strategy: The Cl-t-Boc group provides orthogonal protection that can be selectively removed under mild acidic conditions.

Basic Information

Product Name	Glycine, n-[(2-Chloro-1,1-Dimethylethoxy)Carbonyl]- (9Ci)
CAS No.	38254-31-8
Molecular Formula	C7H12ClNO4
Molecular Weight	209.63 g/mol
Synonyms	N-(2-Chloro-1,1-dimethylethoxycarbonyl)glycine; N-(Chloro-tert-butoxycarbonyl)glycine; Glycine, N-[(2-chloro-1,1-dimethylethoxy)carbonyl]-; Cl-t-Boc-Gly-OH; 2-[(2-Chloro-1,1-dimethylethoxy)carbonylamino]acetic acid; N-(2-Chloro-tert-butoxycarbonyl)glycine; Boc-Gly-OH, 2-Chloro derivative; (2-Chloro-tert-butoxycarbonylamino)acetic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material that meets high-purity specifications suitable for research and pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. Quality is assured through analytical techniques including HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.