Description

[Sar1, Leu8]-Angiotensin II Acetate Hydrate is a synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, featuring specific amino acid substitutions at positions 1 and 8. This modification is critical for research into cardiovascular physiology, receptor binding studies, and the development of novel therapeutic agents. It is an essential biochemical tool for pharmaceutical R&D, academic laboratories, and biotechnology companies focused on hypertension, renal function, and signal transduction pathways.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of the renin-angiotensin system (RAS), blood pressure regulation, and vascular smooth muscle contraction.
• Pharmacological Assays: Serves as a key ligand in receptor binding and competition assays to characterize Angiotensin II receptor subtypes (AT1 and AT2).
• Drug Discovery & Development: A vital intermediate and biochemical tool in the screening and development of novel antihypertensive drugs and receptor antagonists.
• Cell Signaling Studies: Employed to investigate intracellular calcium mobilization, G-protein coupled receptor (GPCR) activation, and related second messenger pathways.
• Academic & Clinical Studies: Facilitates fundamental research into cardiovascular diseases, kidney function, and endocrine regulation in university and hospital laboratories.

Basic Information

Product Name	[Sar1, Leu8]-Angiotensin II Acetate Hydrate
CAS No.	38027-93-9
Molecular Formula	C49H69N13O11 • xC2H4O2 • yH2O
Molecular Weight	~1032.2 g/mol (anhydrous free base)
Synonyms	Sar-Arg-Val-Tyr-Val-His-Pro-Leu-OH (Sar1, Leu8 substitution); [Sar1, Leu8]-Ang II; Angiotensin II (1-8) heptapeptide analog; [Sar1,Ile8]-Angiotensin II related analog; H-Sar-Arg-Val-Tyr-Val-His-Pro-Leu-OH acetate salt; ATII analog; Vasoconstrictor peptide analog
EINECS	Contact for details

Quality Control

Every batch of [Sar1, Leu8]-Angiotensin II Acetate Hydrate is manufactured and analyzed under strict quality management systems. Our products undergo rigorous purity verification using advanced chromatographic and spectroscopic techniques to ensure consistency and reliability for critical research applications. Certificates of Analysis (COA) detailing purity, identity, and content are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95.0%
Assay (Peptide Content)	≥ 80.0% (by weight)
Water Content (KF)	≤ 10.0%
Acetate Content (IC)	3.0 - 8.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.