Description

5-Bromo-4-Ethynylpyrimidine CAS NO 37972-19-3 is a high-value halogenated pyrimidine derivative featuring a reactive ethynyl group. This compound is a critical pharmaceutical intermediate and organic building block for the synthesis of complex molecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of advanced polymers and conductive materials.
• Chemical Biology & Proteomics: Employed as a click chemistry reagent for bioconjugation and probe development due to its alkyne functionality.
• Organic Synthesis Research: A versatile reagent for palladium-catalyzed cross-coupling reactions (e.g., Sonogashira, Suzuki) to create complex heterocyclic systems.
• Ligand Development: Used in the preparation of novel ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	5-Bromo-4-Ethynylpyrimidine
CAS No.	37972-19-3
Molecular Formula	C6H3BrN2
Molecular Weight	183.01 g/mol
Synonyms	4-Ethynyl-5-bromopyrimidine; 5-Bromo-4-ethynylpyrimidine; 4-Ethynyl-5-bromo-pyrimidine; Pyrimidine, 5-bromo-4-ethynyl-; 5-Bromo-4-pyrimidinylacetylene
EINECS	Contact for details

Quality Control

Our 5-Bromo-4-Ethynylpyrimidine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality management system adheres to cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.