Description

Pyrimidine, 2-Chloro-4-Ethynyl- (9Ci) is a specialized halogenated and alkynyl-substituted pyrimidine derivative, serving as a high-value synthetic intermediate. This compound is critical for constructing complex molecular architectures, particularly in advanced pharmaceutical research and fine chemical synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications such as medicinal chemistry, ligand synthesis, and the development of novel organic electronic materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially kinase inhibitors and antiviral agents.
• Agrochemical Research: Used in the development of new herbicides and fungicides with targeted modes of action.
• Material Science: Serves as a precursor for organic semiconductors, conductive polymers, and metal-organic frameworks (MOFs).
• Chemical Biology: Employed in the synthesis of molecular probes and bioconjugates for studying biological processes.
• Cross-Coupling Reactions: The ethynyl group makes it a valuable substrate for Sonogashira and other palladium-catalyzed coupling reactions.
• Ligand Synthesis: Used to create novel chelating ligands for catalysis and metal ion sensing applications.

Basic Information

Product Name	Pyrimidine, 2-Chloro-4-Ethynyl- (9Ci)
CAS No.	37968-69-7
Molecular Formula	C6H3ClN2
Molecular Weight	138.55 g/mol
Synonyms	2-Chloro-4-ethynylpyrimidine; 4-Ethynyl-2-chloropyrimidine; 2-Chloro-4-ethynyl-pyrimidine; 2-Chloro-4-ethynylpyrimidine (9CI); 2-Chloro-4-ethynylpyrimidine, 9CI; 4-Ethynyl-2-chloro-pyrimidine; 2-Chloro-4-ethynylpyrimidine (9CI); 2-Chloro-4-ethynylpyrimidine, 9CI
EINECS	Contact for details

Quality Control

Our Pyrimidine, 2-Chloro-4-Ethynyl- (9Ci) is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.