Description

Sar-Arg-Val-Tyr-Ile-His-Pro-Ile CAS NO 37827-06-8 is a synthetic peptide sequence, also known as Saralasin, which functions as a competitive angiotensin II receptor antagonist. This compound is of significant value in biochemical and pharmacological research for studying the renin-angiotensin system (RAS), a key regulator of blood pressure and fluid balance. It is primarily needed by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on cardiovascular disease, hypertension models, and peptide-based therapeutic discovery.

Application

• Biochemical Research: Used as a specific tool to antagonize angiotensin II receptors in in vitro and ex vivo studies of the RAS pathway.
• Pharmacological Studies: Serves as a reference standard in assays investigating blood pressure regulation, vascular tone, and aldosterone secretion.
• Drug Discovery & Development: Acts as a lead compound or comparator in the development of novel antihypertensive agents and angiotensin receptor blockers (ARBs).
• Diagnostic Reagent Manufacturing: Utilized in the production of test kits and assays for clinical research into cardiovascular conditions.
• Academic Research: Employed in university and institutional labs for fundamental studies on peptide-receptor interactions and signal transduction.

Basic Information

Product Name	Sar-Arg-Val-Tyr-Ile-His-Pro-Ile
CAS No.	37827-06-8
Molecular Formula	C45H68N14O10
Molecular Weight	941.1 g/mol
Synonyms	Saralasin; [Sar1, Ala8]-Angiotensin II; 1-Sarcosine-8-alanine-angiotensin II; Sar1-Ala8-Angiotensin II; Angiotensin II Antagonist; [Sar1,Ala8]Ang II; NSC 401005; UNII-4X6E73C6OQ
EINECS	Contact for details

Quality Control

Our Sar-Arg-Val-Tyr-Ile-His-Pro-Ile is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.