Description

Cyclo(-Pro-Gly)3 CAS NO 37783-51-0 is a synthetic cyclic peptide composed of repeating proline-glycine units, forming a unique and constrained structural motif. This specific conformation is of significant interest in pharmaceutical research and advanced material science for its potential to modulate biological activity and enhance stability. It is primarily utilized by researchers and developers in the fields of peptide-based drug discovery, biomaterials engineering, and as a specialized building block in organic synthesis.

Application

• Pharmaceutical Research: As a scaffold or model compound for studying peptide conformation, protein-protein interactions, and for the development of novel therapeutic agents.
• Drug Discovery: Serving as a constrained peptide backbone in medicinal chemistry to improve metabolic stability and bioavailability of peptide leads.
• Biomaterials Science: Utilized in the design and synthesis of advanced biomaterials, hydrogels, and tissue engineering scaffolds due to its predictable folding properties.
• Chemical Biology: Employed as a molecular probe to investigate biological pathways and enzyme mechanisms.
• Organic Synthesis: Acts as a sophisticated chiral building block or template for the synthesis of complex natural product analogs and macrocycles.
• Cosmeceutical Development: Investigated for potential use in advanced skincare formulations targeting collagen modulation and skin repair.

Basic Information

Product Name	Cyclo(-Pro-Gly)3
CAS No.	37783-51-0
Molecular Formula	C18H24N6O6
Molecular Weight	420.42 g/mol
Synonyms	Cyclo(Pro-Gly)3; Cyclo(L-Prolyl-glycyl)3; Cyclic(Pro-Gly)3; c(Pro-Gly)3; Cyclo(Pro-Gly-Pro-Gly-Pro-Gly); 1,4,7-Triazacyclotetradecane-2,5,8-trione, 10,13,16-trimethyl-; Cyclic tripeptide Pro-Gly-Pro-Gly-Pro-Gly; H-c(Pro-Gly)3-OH
EINECS	Contact for details

Quality Control

Our Cyclo(-Pro-Gly)3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral purity assessment. Certificates of Analysis (COA) detailing all specifications are provided to ensure the material meets the rigorous standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.