Description

Pglu-L-Ala-L-His-Nh2 is a synthetic dipeptide derivative, specifically pyroglutamyl-L-alanyl-L-histidinamide. This compound is a valuable building block in peptide synthesis and biochemical research, offering high purity and defined stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide-based drug discovery, enzyme substrate studies, and the development of bioactive molecules.

Application

• Peptide Synthesis Intermediate: A key protected fragment for the solid-phase or solution-phase synthesis of longer, more complex peptide sequences.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving histidine or glutamine metabolism.
• Pharmaceutical R&D: Serves as a precursor or model compound in the discovery and development of novel therapeutic peptides and peptidomimetics.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in analytical laboratories.
• Neuroscience Studies: Potential application in research related to neuropeptides and their receptors due to the presence of the histidine moiety.

Basic Information

Product Name	Pglu-L-Ala-L-His-Nh2
CAS No.	37666-99-2
Molecular Formula	C14H22N6O4
Molecular Weight	338.36 g/mol
Synonyms	Pyroglutamyl-L-alanyl-L-histidinamide; L-Pyroglutamyl-L-alanyl-L-histidinamide; pGlu-Ala-His-NH2; 5-Oxo-L-prolyl-L-alanyl-L-histidinamide; (S)-2-((S)-2-(2-Amino-1H-imidazol-5-yl)acetamido)propanamido)-5-oxopyrrolidine-2-carboxamide; NSC 334905; L-Histidinamide, L-pyroglutamyl-L-alanyl-
EINECS	Contact for details

Quality Control

Our Pglu-L-Ala-L-His-Nh2 is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and identity confirmation by mass spectrometry and NMR. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.