Description

Pglu-L-His-L-Nle-Nh2 is a synthetic peptide derivative of interest in advanced biochemical research and pharmaceutical development. This compound serves as a crucial building block and research tool for studying peptide-receptor interactions and metabolic pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, diagnostic tools, and biochemical probes.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the synthesis and study of novel peptide-based therapeutics.
• Biochemical Assay Development: For use in enzyme inhibition studies, receptor binding assays, and other in vitro diagnostic applications.
• Metabolic Pathway Analysis: As a probe or substrate in research focused on hormone regulation and metabolic processes.
• Academic Research: A valuable tool in university and institutional labs for fundamental studies in peptide chemistry and molecular biology.
• Peptide Library Synthesis: Used in the construction of combinatorial peptide libraries for high-throughput screening and drug discovery.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in peptide manufacturing.

Basic Information

Product Name	Pglu-L-His-L-Nle-Nh2
CAS No.	37666-93-6
Molecular Formula	C20H31N7O5
Molecular Weight	449.51 g/mol
Synonyms	Pyroglutamyl-Histidyl-Norleucinamide; L-Pyroglutamyl-L-histidyl-L-norleucinamide; Pglu-His-Nle-NH2; TRH Analogue; Thyrotropin-Releasing Hormone Fragment (pGlu-His-Nle-NH2); 5-Oxo-L-prolyl-L-histidyl-L-norleucinamide; (S)-2-(2-((S)-5-Oxopyrrolidine-2-carboxamido)-3-(1H-imidazol-4-yl)propanamido)-N-(2-amino-2-oxoethyl)hexanamide
EINECS	Contact for details

Quality Control

Our Pglu-L-His-L-Nle-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and stringent controls for residual solvents and related substances. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.