Description

Pglu-L-His-L-Nva-Nh2 CAS NO 37666-91-4 is a synthetic tripeptide derivative, specifically a pyroglutamyl-histidyl-norvalinamide. This compound is of significant interest in advanced biochemical research and pharmaceutical development due to its unique structural motif, which can influence biological activity and stability. It serves as a critical building block or reference standard for researchers in medicinal chemistry and peptide science. Target industries include pharmaceutical R&D, biotechnology, and academic institutions focused on developing novel therapeutic agents or diagnostic tools.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the synthesis and screening of novel peptide-based therapeutics.
• Medicinal Chemistry Studies: For structure-activity relationship (SAR) studies to optimize peptide stability, bioavailability, and receptor binding affinity.
• Biochemical Assay Development: Utilized as a substrate, inhibitor, or ligand in enzymatic and receptor-binding assays to study specific biological pathways.
• Academic Research: Serves as a specialized reagent in university and institutional labs for fundamental studies in peptide science and molecular biology.
• Cosmeceutical R&D: Potential application in the research of bioactive peptides for advanced skincare formulations targeting specific cellular functions.

Basic Information

Product Name	Pglu-L-His-L-Nva-Nh2
CAS No.	37666-91-4
Molecular Formula	C17H25N7O5
Molecular Weight	407.43 g/mol
Synonyms	Pyroglutamyl-histidyl-norvalinamide; Pyroglutamyl-L-histidyl-L-norvalinamide; L-Pyroglutamyl-L-histidyl-L-norvalinamide; pGlu-His-Nva-NH2; pGlu-L-His-L-Nva-amide; 5-Oxo-L-prolyl-L-histidyl-L-norvalinamide; (S)-2-(2-((S)-1-Hydroxy-3-(1H-imidazol-4-yl)propan-2-ylamino)-2-oxoethyl)-5-oxopyrrolidine-1-carboxamide (related IUPAC form); H-pGlu-His-Nva-NH2
EINECS	Contact for details

Quality Control

Our Pglu-L-His-L-Nva-Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and MS for structural confirmation, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.