Description

L-Leucyl-L-Seryl p-Nitro-L-Phenylalanyl-L-Norleucyl-L-Alanyl-L-Leucine Methyl Ester is a synthetic peptide derivative of significant interest in advanced biochemical research and pharmaceutical development. Its complex structure, featuring a p-nitro-phenylalanine moiety, makes it a valuable tool for studying enzyme-substrate interactions and protease specificity. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in peptide chemistry, medicinal chemistry, and proteomics. Its defined sequence allows for precise investigation into biological pathways and the development of novel therapeutic agents.

Application

• Biochemical Research: Serves as a specialized substrate or inhibitor for studying the activity and kinetics of proteolytic enzymes like chymotrypsin and related serine proteases.
• Pharmaceutical Development: Used as a key intermediate or reference standard in the design and synthesis of novel peptide-based drugs and diagnostic agents.
• Proteomics & Enzymology: Employed in assays to characterize enzyme specificity, map active sites, and understand protein-protein interaction mechanisms.
• Academic Research: A critical reagent in university and institutional labs for graduate-level studies in advanced organic synthesis, peptide chemistry, and molecular biology.
• Quality Control: Acts as a high-purity analytical standard for calibrating equipment and validating methods in QC laboratories within the biotech and pharmaceutical sectors.

Basic Information

Product Name	L-Leucyl-L-Seryl p-Nitro-L-Phenylalanyl-L-Norleucyl-L-Alanyl-L-Leucine Methyl Ester
CAS No.	37589-79-0
Molecular Formula	C41H60N8O11
Molecular Weight	840.97 g/mol
Synonyms	Leu-Ser-pNO2-Phe-Nle-Ala-Leu-OMe; Chymotrypsin Substrate III; N-Succinyl-Ala-Ala-Pro-Phe-p-nitroanilide related peptide; Suc-AAPF-pNA analog; p-Nitro-L-phenylalanine containing hexapeptide methyl ester; Protease substrate peptide; L-Leu-L-Ser-pNO2-Phe-L-Nle-L-Ala-L-Leu methyl ester; N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-Methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-nitrophenyl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]-L-leucine methyl ester
EINECS	Contact for details

Quality Control

Our L-Leucyl-L-Seryl p-Nitro-L-Phenylalanyl-L-Norleucyl-L-Alanyl-L-Leucine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring traceability and compliance with research-grade standards. Our commitment to quality supports reproducible and reliable results in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed in a dry environment after each use to prevent degradation. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Specific Rotation	Contact for details
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.