Description

n-[(2-Hydroxy-1-Naphthalenyl)Methylene]-L-Val-L-Ile-L-Ala-Oet is a synthetic, optically active tripeptide derivative featuring a naphthalene-based chromophore. This compound is valued for its role as a key intermediate in advanced peptide synthesis and pharmaceutical research, where precise stereochemistry and functional group compatibility are critical. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and biochemical probes.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of complex peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and for investigating protein-peptide interactions due to its specific chiral centers.
• Protease Inhibitor Development: Acts as a core structure for designing and screening novel inhibitors targeting specific proteases.
• Fluorescent Probe Synthesis: The naphthalene moiety enables its use as a precursor for creating fluorescently labeled peptides for diagnostic and imaging applications.
• Academic & Industrial R&D: Employed in research laboratories for method development in solid-phase and solution-phase peptide synthesis.
• Fine Chemical Production: Used in the custom synthesis of specialty peptides and chiral compounds for various industrial applications.

Basic Information

Product Name	n-[(2-Hydroxy-1-Naphthalenyl)Methylene]-L-Val-L-Ile-L-Ala-Oet
CAS No.	37580-37-3
Molecular Formula	C30H39N3O5
Molecular Weight	521.65 g/mol
Synonyms	N-[(2-Hydroxy-1-naphthyl)methylene]-L-valyl-L-isoleucyl-L-alanine ethyl ester; L-Alanine, N-[2-[(2-hydroxy-1-naphthalenyl)methylene]amino]-1-oxo-3-methylbutyl]-L-isoleucyl-, ethyl ester; Ethyl N-[(2-hydroxy-1-naphthyl)methylene]valylisoleucylalaninate; Val-Ile-Ala-OEt Schiff Base (naphthol); Tripeptide derivative CAS 37580-37-3; H-Val-Ile-Ala-OEt · 2-Hydroxy-1-naphthaldehyde Schiff base
EINECS	Contact for details

Quality Control

Our n-[(2-Hydroxy-1-Naphthalenyl)Methylene]-L-Val-L-Ile-L-Ala-Oet is produced under controlled conditions to ensure high chemical purity and consistent batch-to-batch performance. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment, supporting compliance with rigorous R&D and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% (by Chiral HPLC)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.