Description

H-Phe-Pro-Arg-Oh CAS NO 37553-80-3 is a synthetic tripeptide derivative, specifically the C-terminal carboxylic acid form of the sequence Phenylalanine-Proline-Arginine. This compound is a key intermediate and building block in advanced pharmaceutical research and peptide synthesis. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in the development of novel therapeutic agents, enzyme inhibitors, and diagnostic tools.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of complex peptide-based active pharmaceutical ingredients (APIs) and prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving serine proteases like thrombin, due to the arginine residue.
• Peptide Library Construction: A valuable component in solid-phase and solution-phase peptide synthesis for creating diverse compound libraries for screening.
• Diagnostic Reagent Development: Serves as a core structure in the design of fluorescent or chromogenic substrates for diagnostic assays.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of peptide therapeutics.

Basic Information

Product Name	H-Phe-Pro-Arg-Oh
CAS No.	37553-80-3
Molecular Formula	C20H30N6O4
Molecular Weight	418.49 g/mol
Synonyms	FPR-OH; H-Phe-Pro-Arg-OH; L-Phenylalanyl-L-prolyl-L-arginine; Phe-Pro-Arg; FPR Tripeptide; Phenylalanine-Proline-Arginine; N-[(2S)-1-[[(2S)-1-[(2S)-2-Amino-3-phenylpropanoyl]pyrrolidin-2-yl]carbonyl]-5-(diaminomethylideneamino)pentyl]carbamic acid
EINECS	Contact for details

Quality Control

Our H-Phe-Pro-Arg-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via mass spectrometry (MS) and infrared (IR) spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.