Description

D-4-Pyridylalanine is a specialized non-proteinogenic amino acid derivative featuring a pyridyl side chain, serving as a crucial chiral building block and intermediate in advanced organic synthesis. Its unique structure makes it invaluable for constructing complex molecules with high precision and biological relevance. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and biochemical probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in oncology and neurology.
• Peptide Chemistry: Used in solid-phase peptide synthesis (SPPS) to incorporate unnatural amino acids, enhancing peptide stability and bioactivity.
• Bioconjugation & Probe Development: Serves as a linker or functional handle for creating fluorescent probes, affinity labels, and antibody-drug conjugates (ADCs).
• Chemical Biology Research: Employed in studying enzyme mechanisms, receptor-ligand interactions, and metabolic pathways.
• Catalyst & Ligand Synthesis: Acts as a precursor for synthesizing novel chiral ligands used in asymmetric catalysis.
• Academic & R&D Laboratories: Essential for methodological studies in organic synthesis and medicinal chemistry.

Basic Information

Product Name	D-4-Pyridylalanine
CAS No.	37535-50-5
Molecular Formula	C8H10N2O2
Molecular Weight	166.18 g/mol
Synonyms	D-4-Pyridylalanine; (R)-2-Amino-3-(4-pyridyl)propanoic acid; D-β-(4-Pyridyl)alanine; (R)-3-(4-Pyridyl)alanine; H-D-4-Pal-OH; D-4-Pyridyl-Ala; D-Pyrid-4-yl-Alanine; (R)-2-Amino-3-(pyridin-4-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our D-4-Pyridylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.