Description

Hemoglobin Freiburg CAS NO 37280-23-2 is a specific, naturally occurring variant of hemoglobin, a critical oxygen-transporting protein in red blood cells. This variant is of significant interest in biochemical and medical research for studying the structure-function relationships of hemoglobin and its role in oxygen affinity disorders. It serves as a valuable reference standard and research reagent for scientists and institutions focused on hematology, genetic disorders, and protein biochemistry. Its precise characterization is essential for advancing diagnostic methodologies and therapeutic research.

Application

• Biochemical Research: Used as a high-purity reference standard in studies investigating hemoglobin structure, function, and oxygen-binding kinetics.
• Clinical Diagnostics Development: Serves as a critical control material in the research and validation of diagnostic assays for hemoglobinopathies and thalassemias.
• Pharmaceutical Research: Employed in preclinical studies to understand the impact of specific hemoglobin variants on drug metabolism and efficacy.
• Academic & Institutional Studies: A key reagent for university and research institute laboratories focusing on molecular biology, genetics, and protein science.
• Quality Control in Diagnostics: Used by in-vitro diagnostic (IVD) manufacturers to calibrate instruments and ensure the accuracy of hemoglobin analysis systems.

Basic Information

Product Name	Hemoglobin Freiburg
CAS No.	37280-23-2
Molecular Formula	C2952H4664N812O840S8Fe4 (Hemoglobin tetramer, α2β2)
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Hb Freiburg; Hemoglobin variant Freiburg; Unstable hemoglobin Freiburg; Hb Fribourg; α-23(B4) Glutamic acid deleted; α23 Glu→0; Deletion of glutamic acid at position 23 of the α-globin chain
EINECS	Contact for details

Quality Control

Our Hemoglobin Freiburg is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is characterized using advanced analytical techniques including HPLC, electrophoresis, and spectroscopic methods to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, physical form, and specific test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (HPLC/Electrophoresis)	Conforms to standard for Hemoglobin Freiburg
Purity (HPLC)	≥ 95%
Protein Content (Biuret)	≥ 90%
Methemoglobin Content	≤ 5%
Solubility	Clear solution in buffer
Water Content (KF)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.