Description

Heparin Calcium CAS NO 37270-89-6 is a low molecular weight heparin derivative, a calcium salt form of the naturally occurring glycosaminoglycan. This compound is critically important as an anticoagulant and antithrombotic agent, offering a more predictable pharmacokinetic profile than unfractionated heparin. It is essential for manufacturers in the pharmaceutical and biopharmaceutical sectors requiring a reliable active pharmaceutical ingredient (API) for injectable anticoagulant therapies, diagnostic reagents, and research applications.

Application

• Primary Active Pharmaceutical Ingredient (API) for the formulation of low molecular weight heparin (LMWH) injectable anticoagulant drugs.
• Key component in the production of blood collection tubes and devices (e.g., Vacutainer®) to prevent blood clotting.
• Used in in-vitro diagnostic (IVD) kits and reagents for coagulation testing and hematology studies.
• Essential for biomedical research involving blood coagulation pathways, thrombosis models, and cell surface interactions.
• Application in the surface coating of medical devices like catheters and stents to impart antithrombogenic properties.
• Utilized in cell culture media as a growth factor stabilizer, particularly in stem cell and primary cell cultures.

Basic Information

Product Name	Heparin Calcium
CAS No.	37270-89-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Calcium Heparin; Heparin Calcium Salt; Heparin Ca; Low Molecular Weight Heparin Calcium; LMWH-Calcium; α-Heparin Calcium Salt; Heparin, calcium salt; Antithrombin III cofactor calcium salt
EINECS	253-404-3

Quality Control

Our Heparin Calcium is manufactured under strict quality management systems, with production potentially aligned to cGMP (current Good Manufacturing Practice) guidelines for pharmaceutical ingredients. Each batch undergoes comprehensive analytical testing, including but not limited to potency (anti-Factor Xa and anti-Factor IIa activity), molecular weight distribution, and purity assays. Certificates of Analysis (COA) documenting compliance with relevant pharmacopeial standards (e.g., USP, EP) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent absorption of atmospheric moisture, which can affect potency and stability. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms
pH (Solution)	5.0 - 7.5
Assay (Anti-Factor Xa Activity)	90.0% - 110.0% of labeled potency
Molecular Weight Distribution	Conforms to LMWH criteria
Protein	≤ 1.0%
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 5.0%
Bacterial Endotoxins	< 0.01 IU per anti-Factor Xa IU
Sterility (if supplied sterile)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.