Description

Hemoglobin Kempsey CAS NO 37248-11-6 is a specific, naturally occurring variant of hemoglobin, a critical oxygen-transporting protein in red blood cells. This variant is of significant interest in biochemical and medical research due to its altered oxygen-binding properties, which provide a model for studying hemoglobin function and related pathologies. It is primarily utilized by research institutions, diagnostic manufacturers, and pharmaceutical companies engaged in hematology studies, biosensor development, and the investigation of blood disorders.

Application

• Biochemical Research: Used as a standard or model protein in studies of oxygen transport, hemoglobin kinetics, and allosteric regulation.
• Diagnostic Development: Serves as a key component in the calibration and validation of clinical analyzers and point-of-care devices for blood gas and hemoglobin analysis.
• Hematology Studies: Employed in research focused on hemoglobinopathies, understanding the structural and functional impact of specific amino acid substitutions.
• Pharmaceutical Research: Used in drug discovery programs targeting sickle cell disease, thalassemia, and other disorders related to hemoglobin.
• Biosensor Fabrication: Acts as a biological recognition element in the development of optical or electrochemical sensors for oxygen and nitric oxide.
• Educational & Reference Material: Supplied to academic and teaching laboratories for advanced coursework in protein chemistry and molecular biology.

Basic Information

Product Name	Hemoglobin Kempsey
CAS No.	37248-11-6
Molecular Formula	C2952H4664N812O840S8Fe4
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Hb Kempsey; Hemoglobin variant Kempsey; α-2 β-2(99)(G1)Asp->Asn; Hemoglobin α2β299 Asp→Asn; High-Oxygen-Affinity Hemoglobin Kempsey; Unstable Hemoglobin Kempsey; Oxyhemoglobin Kempsey; Deoxyhemoglobin Kempsey
EINECS	Contact for details

Quality Control

Our Hemoglobin Kempsey is produced and handled under stringent quality protocols. Each batch is characterized for identity, purity, and functional activity using advanced analytical techniques. Certificates of Analysis (COA) detailing specifications such as purity (by HPLC), methemoglobin content, and oxygen affinity are available upon request to ensure it meets your specific research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (IR)	Conforms
Purity (HPLC)	≥ 95%
Methemoglobin Content	< 5%
Protein Content (Biuret)	≥ 90%
Solubility	Clear, red solution in buffer
P50 (Oxygen Affinity)	Contact for details
Endotoxin	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.