Description

Promelittin is a synthetic polypeptide analog of melittin, the primary active component of bee venom. This compound is of significant interest in biochemical and pharmacological research due to its ability to interact with cell membranes and modulate biological activity. It serves as a critical tool for researchers in the life sciences, particularly in the study of antimicrobial peptides, cytolytic mechanisms, and drug delivery systems. The product is supplied as Promelittin CAS NO 37231-70-2, ensuring precise identification for global sourcing and regulatory compliance.

Application

• Biochemical Research: Used as a model peptide for studying membrane permeabilization, pore formation, and the structure-activity relationships of lytic peptides.
• Antimicrobial Studies: Investigated for its potential antimicrobial properties against bacteria, fungi, and other pathogens in in-vitro assays.
• Drug Delivery Systems: Explored as a cell-penetrating peptide (CPP) vector to enhance the cellular uptake of therapeutic agents, including nucleic acids and chemotherapeutic drugs.
• Cancer Research: Evaluated for its selective cytolytic activity against cancer cell lines, contributing to the development of novel oncological therapies.
• Neuroscience: Applied in studies of ion channel modulation and neuronal signaling pathways due to its membrane-disruptive properties.
• Pharmaceutical Development: Serves as a reference standard and a starting material for the synthesis and optimization of novel peptide-based therapeutics.

Basic Information

Product Name	Promelittin
CAS No.	37231-70-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Melittin analog; Synthetic melittin; Promelittin peptide; Polyporin A; Melittin-related peptide; Bee venom peptide analog; H-Mel-OH (related); Lytic peptide analog
EINECS	Contact for details

Quality Control

Our Promelittin is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including purity assessment by HPLC, peptide content determination, and identity confirmation via mass spectrometry. We provide full traceability and Certificates of Analysis (COA) are available upon request to support your research and development documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.